5 Simple Techniques For https://www.ceesdekker.net
5 Simple Techniques For https://www.ceesdekker.net
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‘Certainly, which is about ideal. I hunt for a Actual physical understanding of biological devices in a bottom-up way. I feel you could distinguish 3 traces of investigate in my group for the time being. The primary fears chromosome construction: How will you get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation tactics that allow for us to study how, as an example, SMC proteins loop DNA (movie on Youtube) so as to build up chromosomes.
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Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metal clusters
2015, discovery that condensin can be a very flexible protein framework; and very first detection of DNA knots using nanopores
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing system. The key of said daily life, I think, lies while in the interactions, the interplay of People molecules. The massive issue concerning the origin of lifetime is still unanswered. How did we at any time evolve from easy molecules in the very advanced methods we see nowadays? We do not know. I want to operate on These types of large, open thoughts.’
Nanopores represent an elegant and flexible Instrument to measure single molecules. We study novel detection modes with strong-state nanopores in addition to a variety of strategies to evaluate proteins with nanopores. Assignments encompass the next:
2003, demonstrated the ceesdekker.net initial biosensors created from a carbon nanotube; resolved the composition and system of DNA mend proteins; and discovery of a whole new approach for fabricating strong-point out nanopores for DNA translocation
Pretty amazing, but that wasn’t really the place my desire lay. I desired to pioneer And that i experienced the sensation that was not probable, because the most exciting essential insights had presently been uncovered. But my subject experienced created a lot of remarkable new resources to measure particular person molecules. I made a decision that I desired to use this to biology, to take a look at it from the Actual physical point of view.’
Testing pseudotopological and nontopological versions for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Numerous new phenomena were being uncovered, and he and his study team proven a number one placement in this industry of analysis. Dekker and his research group discovered new physics of nanotubes together with explored the feasibility of molecular electronics. In 1998, they had been the main to create a transistor based on an individual nanotube molecule.
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Solid-state nanopores have proven to become a remarkably flexible probe for single-molecule Evaluation of DNA. I will explain many of our recent conclusions – precisely DNA knots – as well as our endeavours to extend the abilities of stable-condition nanopores even even more, while in the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.